在辅助生殖技术治疗和自然受孕的孕妇中，可乐摄入量与不良分娩结局的关联:一项出生队列研究

DOI：10.1080/14647273.2023.2286347

Abstract

The influence of cola intake on birth outcomes is unclear. This study sought to describe and compare the associations between cola intake and adverse birth outcomes among women following assisted reproductive technology (ART) and women spontaneously conceived (SC). Participants (736 ART women and 1,270 SC women) were from the Chinese National Birth Cohort collected in Anhui province. Cola intake was assessed by self-reported questionnaires at each trimester. Outcome measures including preterm birth (PTB) and low birth weight (LBW) were extracted from medical records. The association between cola intake during pregnancy and PTB was found using multivariable log-binomial regression in combined ART and SC women. Separately, for ART women, cola intake during pregnancy increased the risk of PTB (risk ratios were 2.10, 1.65, and 1.81 for all three trimesters, respectively, all p<0.05), and cola intake in the 1st trimester increased the risk of LWB (risk ratio 2.58, 95% confidence interval 1.29 to 5.16). Cola intake during pregnancy was not associated with PTB or LBW for SC women. Our findings indicate a detrimental effect of cola intake during pregnancy on birth outcomes for ART women. Thus, avoidance of cola intake should be counselled by medical doctors in women prescribed with ART treatment.

摘要
可乐摄入量对出生结果的影响尚不清楚。本研究旨在描述和比较可乐摄入量与辅助生殖技术(ART)和自然受孕(SC)妇女不良分娩结局之间的关系。参与者(736名ART妇女和1270名SC妇女)来自安徽省收集的中国国家出生队列。每三个月通过自我报告的问卷来评估可乐的摄入量。结果测量包括早产(PTB)和低出生体重(LBW)从医疗记录中提取。在联合ART和SC的妇女中，使用多变量对数二项回归发现怀孕期间可乐摄入量与PTB之间的关联。另外，对于ART妇女，怀孕期间摄入可乐增加了PTB的风险(三个妊娠期的风险比分别为2.10、1.65和1.81，均p<0.05)，妊娠早期摄入可乐增加了LWB的风险(风险比2.58,95%置信区间1.29至5.16)。妊娠期可乐摄入与妊娠期PTB或LBW无关。我们的研究结果表明，在怀孕期间摄入可乐对抗逆转录病毒治疗妇女的分娩结果有不利影响。因此，在接受抗逆转录病毒治疗的妇女中，医生应建议避免可乐的摄入。