Associations between early life parent-child separation and shortened telomere length and psychopathological outcomes during adolescence

Highlight：国内首次报道亲子分离相关的端粒侵蚀加速可在青春期慢性病尚未发展的情况下被识别，提示端粒可能是健康监测和风险预测的重要工具。

Abstract

Background: Given the ethical limitations of exposing children to experimentally manipulated adverse experiences, evidence of the effects of parent-child separation on subsequent psychopathology are based mostly on animal studies. Left-behind children phenomenon resulting from rural-urban mobility in China offers unique "natural experiments" to explore the long-term physical and mental health consequences of parent-child separation in childhood.

Objective: To test the associations between parent-child separation with telomere length (TL) and psychopathology during adolescence.

Method: A total of 710 adolescents (age: M = 16.86, SD = 1.52) were recruited from local schools in rural area of Fuyang, one of the top inland areas for outward migration in Anhui province, China. Parent-child separation was collected through face to face interview. The MacArthur Health & Behavior Questionnaire (HBQ) was used to assess internalizing and externalizing symptoms. Quantitative polymerase chain reaction was used to measure buccal TL.

Results: Nearly 60% (399/695) of the participants experienced separation from both parents. Childhood or persistent separation from parents was associated with increased internalizing symptoms (childhood: β = 0.13, 95% CI: 0.02, 0.23; persistent: β = 0.23, 95% CI: 0.14, 0.31), increased externalizing symptoms (childhood: β = 0.17, 95% CI: 0.03, 0.32; persistent: β = 0.23, 95% CI: 0.10, 0.35) and shorter telomere length (childhood: β = -0.16, 95% CI: -0.26, -0.05; persistent: β = -0.13, 95% CI: -0.22, -0.03). Shortened TL was estimated to explain 15.2% and 12.7% of the total effect of separation on internalizing and externalizing symptoms, while internalizing and externalizing symptoms explained 23.4% and 12.3% of the effect of separation on shortened TL.

Conclusion: Childhood and persistent parent-child separation, as experienced by rural left-behind children in China, associates with increased vulnerability for psychopathological symptoms and makers of cellular aging. The challenge for future research is to determine whether short telomere length is in fact a long-term consequence or an underlying vulnerability factor for future mental disorders.

Chen X, Zeng C, Gong C, Zhang L, Wan Y, Tao F, Sun Y. Associations between early life parent-child separation and shortened telomere length and psychopathological outcomes during adolescence. Psychoneuroendocrinology. 2019 May;103:195-202.