Aluminum and magnesium status during pregnancy and placenta oxidative stress and inflammatory mRNA expression: China Ma'anshan birth cohort study

Highlight：本研究旨在探讨产前Al和Mg对胎盘氧化应激和炎症mRNA表达的影响。发现镁可以拮抗铝诱导的胎盘炎症和氧化应激。

Abstract

The aim of this study was to explore the impact of prenatal Al and Mg on placental oxidative stress and inflammatory mRNA expression. A total of 2519 pregnant women from the China Ma’anshan birth cohort participated in this study. Al and Mg levels were measured by inductively coupled plasma mass spectrometry(ICP-MS). Placental stress and inflammatory mRNA expression were assessed by RT-PCR. The median Al levels in the first and second trimesters of pregnancy and in cord blood were higher than the corresponding median Mg levels. Predictors of lower Al and Mg levels included Han ethnicity and high education according to a mixed linear model. Multiple linear regression analysis revealed that Al and Al/Mg levels had a positive association with inflammatory mRNA expression and placental oxidative stress in the second trimester of pregnancy. A negative association existed between Al and Al/Mg levels and inflammatory mRNA expression and placenta oxidative stress in the cord blood, with the exception of IL-1b expression. In conclusion, prenatal Al and Mg status was associated with placental oxidative stress and inflammatory mRNA expression. More preclinical studies are needed to confirm the relevant mechanism.

Wang JQ, Hu YB, Liang CM, Xia X, Li ZJ, Gao H, Sheng J, Huang K, Wang SF, Li Y, Zhu P, Hao JH, Tao FB*. Aluminum and magnesium status during pregnancy and placenta oxidative stress and inflammatory mRNA expression: China Ma'anshan birth cohort study[J]. Environ Geochem Health. 2020.