母亲孕期抑郁症与婴儿行为发育：一种潜在的累积效应

Maternal Perinatal Depression and Infant Behavioural Development: A Potential Cumulative Effect

母亲孕期抑郁症与婴儿行为发育：一种潜在的累积效应

Authors: Lianjie Dou, Xiayu Zhang, Lianman Lei, Yuchen Ye, Shu Sun, Zhaohui Huang, Anhui Zhang, Haiyan He, Hong Tao, Min Yu, Min Zhu, Chao Zhang, Jiahu Hao

Source: Stress And Health

PMID: 40455012

DOI: 10.1002/smi.70055

Abstract

Limited research has examined the relationship between maternal perinatal depression and infant behaviours, as well as the potential cumulative effects. A sample of 686 mother-child pairs from the Wuhu Birth Cohort Study was used. Maternal depression levels were repeatedly assessed during the first trimester, second trimester, third trimester, and 3-months postpartum using the Edinburgh Postnatal Depression Scale. Children's behavioural development at 12 months of age was evaluated using the Ages and Stages Questionnaire. A group-based trajectory model was employed to fit the trajectories of maternal perinatal depression scores. Generalised linear regression models with robust estimation were used to analyse the association between maternal depression scores, depressive symptoms, depression trajectories, and child behavioural development. The postnatal depression score was negatively associated with infant behavioural scores in all 5 domains (β_{communication} (95% CI): -0.23 (-0.38, -0.08), β_gross-motor (95% CI): -0.29 (-0.52, -0.06), β_fine-motor (95% CI): -0.19 (-0.35, -0.02), β_{problem-solving} (95% CI): -0.28 (-0.48, -0.09), β_{personal-social} (95% CI): -0.39 (-0.59, -0.18)), while postpartum depressive symptom was associated with reduced score in the personal-social domain (β (95% CI):-4.01 (-7.15, -0.88)). The high depression score trajectory was associated with decreased scores in communication (β (95% CI): -1.76 (-3.35, -0.18)), problem-solving (β (95% CI): -2.10 (-4.17, -0.03)) and personal-social domain (β (95% CI): -2.50 (-4.68, -0.33)). Additionally, depression in the third trimester was inversely associated with communication (β (95% CI):-2.20 (-4.23, -0.18)). Maternal perinatal depression was negatively correlated with infant behavioural development, and a potential cumulative effect was observed, suggesting that we should pay attention to the entire perinatal period rather than a specific period.

Keywords: behavioural development; depression; infant; post‐pregnancy; pregnancy.

摘要

目前关于产妇围产期抑郁与婴儿行为之间关系以及潜在累积效应的研究尚不多见。本研究选取了芜湖出生队列研究中的686对母婴样本。采用爱丁堡产后抑郁量表，在孕早期、孕中期、孕晚期及产后3个月对产妇抑郁水平进行了多次评估。婴儿12个月时的行为发展通过《年龄与阶段问卷》进行评估。采用基于群体的轨迹模型拟合母亲围产期抑郁症评分的轨迹。使用具有稳健估计的广义线性回归模型分析母亲抑郁症评分、抑郁症状、抑郁轨迹与儿童行为发展之间的关联。产后抑郁评分与婴儿行为评分在所有5个领域均呈负相关（β_沟通（95% CI）：-0.23（-0.38，-0.08），β_粗大运动（95% CI）：-0.29（-0.52，-0.06），β_精细运动（95% CI） ：-0.19（-0.35，-0.02），β_解决问题（95% CI）：-0.28（-0.48，-0.09），β_个人社会（95% CI）： -0.39（-0.59，-0.18）），而产后抑郁症状与个人社会领域得分降低相关（β（95% CI）：-4.01（-7.15，-0.88））。高抑郁得分轨迹与沟通领域得分降低相关（β（95% CI）： -1.76（-3.35，-0.18））、问题解决（β（95% CI）：-2.10（-4.17，-0.03））和个人-社会领域（β（95% CI）：-2.50（-4.68，-0.33））评分降低。此外，第三孕期的抑郁与沟通能力呈负相关（β（95% CI）：-2.20（-4.23，-0.18））。产后抑郁与婴儿行为发展呈负相关，且观察到潜在的累积效应，这表明我们应关注整个围产期而非特定阶段。

关键词：行为发育；抑郁症；婴儿；产后；妊娠。