Associating phthalate exposure during pregnancy with preschooler's FMI, ABSI and BRI trajectories via putative mechanism pathways.

Authors：Gao, H., Zhang, Y., Chen, L. W., Gan, H., Lu, M. J., Huang, B., Tong, J., Geng, M. L., Huang, K., Zhang, C., Zhu, B. B., Shao, S. S., Zhu, P., & Tao, F. B.

Source：Chemosphere. 2023;337:139300.

DOI: 10.1016/j.chemosphere.2023.139300

Abstract：Phthalates are well-known obesogens, but a few studies have explored their impacts on the childhood fat mass index (FMI), body shape index (ABSI) and body roundness index (BRI). Information from 2950 participants recruited in the Ma’anshan Birth Cohort was analyzed. The relationships between six maternal phthalate metabolites and their mixture and childhood FMI, ABSI and BRI were investigated. FMI, ABSI and BRI in children aged 3.5 y, 4.0 y, 4.5 y, 5.0 y, 5.5 y and 6.0 y were calculated. The latent class trajectory modeling categorized the FMI trajectories into “rapidly increasing FMI” (4.71%) and "stable FMI" (95.29%) groups; ABSI trajectories were categorized as “decreasing ABSI” (32.74%), “stable ABSI” (46.55%), “slowly increasing ABSI” (13.26%), “moderately increasing ABSI” (5.27%) and “rapidly increasing ABSI” (2.18%) groups; BRI trajectories were categorized as “increasing BRI” (2.82%), “stable BRI” (19.85%), and “decreasing BRI” (77.34%) groups. Prenatal MEP exposure was associated with repeated measurements of FMI (β = 0.111, 95% CI = 0.002-0.221), ABSI (β = 0.145, 95% CI = 0.023-0.268) and BRI (β = 0.046, 95% CI = -0.005-0.097). Compared with each stable trajectory group, prenatal MEP (OR = 0.650, 95% CI = 0.502-0.844) and MBP (OR = 0.717, 95% CI = 0.984-1.015) were linked to a decreased risk of “decreasing BRI” in children; there was a negative relationship between MBP and the “decreasing ABSI” group (OR = 0.667, 95% CI = 0.487-0.914), and MEP increased the risks of “slowly increasing ABSI” (OR = 1.668, 95% CI = 1.210-2.299) and “rapidly increasing ABSI” (OR = 2.522, 95% CI = 1.266-5.024) in children. Phthalate mixture during pregnancy showed significant relationships with all anthropometric indicator trajectories, with MEP and MBP always being of the largest importance. In conclusion, this study suggested that prenatal phthalate coexposure increased the childhood probability of being in higher ABSI and BRI trajectory groups. That is, children were more likely to be obese when they were exposed to higher levels of some phthalate metabolites and their mixture. The low-molecular weight phthalates, including MEP and MBP, contributed the greatest weights.

Keywords: Anthropometric indicator trajectory; Bioinformatics; Body roundness index; Body shape index; Phthalates.

中文摘要：邻苯二甲酸酯是众所周知的致肥物质，但对其对儿童脂肪质量指数(FMI)、体型指数(ABSI)和体圆度指数(BRI)的影响研究较少。从马鞍山出生队列中招募的2950名参与者的信息进行分析。研究了6种母体邻苯二甲酸酯代谢物及其混合物与儿童FMI、ABSI和BRI的关系。计算3.5岁、4.0岁、4.5岁、5.0岁、5.5岁、6.0岁儿童FMI、ABSI和BRI。潜在轨迹模型将FMI轨迹分为“快速增长FMI”(4.71%)组和“稳定FMI”(95.29%)组;ABSI轨迹分为“下降ABSI”(32.74%)、“稳定ABSI”(46.55%)、“缓慢增加ABSI”(13.26%)、“适度增加ABSI”(5.27%)和“快速增加ABSI”(2.18%)组;“BRI”发展轨迹分为“增加型BRI”(2.82%)、“稳定型BRI”(19.85%)和“减少型BRI”(77.34%)三类。产前MEP暴露与重复测量FMI (β = 0.111, 95% CI = 0.002-0.221)、ABSI (β = 0.145, 95% CI = 0.023-0.268)和BRI (β = 0.046, 95% CI = -0.005-0.097)相关。与各稳定轨迹组相比，产前MEP (OR = 0.650, 95% CI = 0.502-0.844)和MBP (OR = 0.717, 95% CI = 0.984-1.015)与儿童“减少型BRI”的风险降低有关;MBP与“降低ABSI”组呈负相关(OR = 0.667, 95% CI = 0.487 ~ 0.914)， MEP增加了儿童“缓慢增加ABSI”(OR = 1.668, 95% CI = 1.210 ~ 2.299)和“快速增加ABSI”(OR = 2.522, 95% CI = 1.266 ~ 5.024)的风险。怀孕期间邻苯二甲酸盐混合物与所有人体测量指标轨迹都有显著关系，其中MEP和MBP始终是最重要的。总之，本研究表明，产前邻苯二甲酸盐共同暴露增加了儿童时期出现高ABSI和BRI轨迹组的可能性。也就是说，当儿童暴露于高水平的某些邻苯二甲酸酯代谢物及其混合物中时，他们更有可能肥胖。低分子量邻苯二甲酸酯，包括MEP和MBP，贡献了最大的权重。

关键词:人体测量指标轨迹;生物信息学;体圆度指数;体型指数;邻苯二甲酸盐。