Association of Maternal TSH, FT4 with children's BMI trajectories and obesity: a birth cohort study

Authors：Yang M, Zhang S, Teng Y, Ru X, Zhu L, Han Y, Tao X, Cao H, Yan S, Tao F, Huang K. 

Source：J Clin Endocrinol Metab. 2023 Aug 1:dgad441.

DOI: 10.1210/clinem/dgad441.

Abstract：

Objective: To investigate the association between maternal TSH, FT₄ and children's BMI trajectories and obesity.

Method: Based on the Ma'anshan Birth Cohort in China, we repeatedly assayed maternal thyroid functions in three trimesters of pregnancy. Children's height and weight were measured 15 times before six years old. Body fat was assessed when children aged 6. Mplus software was used to fit maternal thyroid hormone trajectories and BMI trajectories. Multivariate logistic regression models and generalized linear models were adopted in data analysis.

Results: Low maternal FT4 trajectory was observed to be related to an increased risk of a high children's BMI trajectory and overweight, with an OR and 95% CI of 1.580 (1.169, 2.135) and 1.505 (1.064, 2.129). Increased maternal FT4 concentrations in the first trimester, second and third trimesters were associated with a decreased risk of high children's BMI trajectories and obesity.There was a positive association between maternal FT4 low trajectory and 6-year-old children's body fat ratio with β and 95% CI of 0.983 (0.138, 1.829). Furthermore, negative correlations between maternal FT4 concentration in the first, second and third trimesters of pregnancy and body fat ratio were observed.

Conclusions: Low maternal FT4 trajectory during pregnancy may predict a high BMI trajectory in children and relate with overweight and high body fat ratio in 6-year-olds. High maternal FT4 concentrations throughout pregnancy may be associated with the decreasing risk of obesity and low body fat ratio in 6-year-old children.

Keywords: BMI; Body fat ratio; FT4; Obesity; TSH; Trajectories.

摘要:

目的:探讨母亲TSH、FT₄与儿童BMI轨迹及肥胖的关系。

方法:以中国马鞍山出生队列为基础，在妊娠3个月反复检测母体甲状腺功能。儿童身高和体重在6岁之前被测量了15次。在儿童6岁时评估体脂。使用Mplus软件拟合母体甲状腺激素轨迹和BMI轨迹。数据分析采用多元逻辑回归模型和广义线性模型。

结果:母亲FT₄轨迹低与儿童BMI轨迹高和超重的风险增加有关，OR和95% CI分别为1.580(1.169,2.135)和1.505(1.064,2.129)。妊娠早期、中期和晚期产妇FT₄浓度升高与儿童高BMI轨迹和肥胖风险降低相关。母亲FT₄低轨迹与6岁儿童体脂率呈正相关，β值为0.983 (0.138,1.829)，95% CI为0.983。此外，妊娠前、中、晚期产妇FT₄浓度与体脂比呈负相关。

结论:妊娠期母亲FT₄轨迹低可能预示儿童BMI轨迹高，并与6岁儿童超重和高体脂率相关。妊娠期间母体FT₄浓度高可能与6岁儿童肥胖和低体脂率风险降低有关。

关键词:体重指数；体脂比；FT₄；肥胖；TSH；轨迹。