妊娠期暴露于单个和组合的全氟烷基和多氟烷基物质对胎盘结构和效率的影响：来自马鞍山出生队列的发现

Impact of Gestational Exposure to Individual and Combined Per- and Polyfluoroalkyl Substances on a Placental Structure and Efficiency: Findings from the Ma'anshan Birth Cohort

妊娠期暴露于单个和组合的全氟烷基和多氟烷基物质对胎盘结构和效率的影响：来自马鞍山出生队列的发现

Authors: Hong Gan, Yanan Xing, Juan Tong, Mengjuan Lu, Shuangqin Yan, Kun Huang, Xiaoyan Wu, Shuman Tao, Hui Gao, Yitao Pan, Jiayin Dai, Fangbiao Tao.

Source: Gan H, Xing Y, Tong J, et al. Impact of Gestational Exposure to Individual and Combined Per- and Polyfluoroalkyl Substances on a Placental Structure and Efficiency: Findings from the Ma'anshan Birth Cohort. Environ Sci Technol. 2024;58(14):6117-6127.

doi:10.1021/acs.est.3c09611

Abstract

Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances (PFASs) is inevitable among pregnant women. Nevertheless, there is a scarcity of research investigating the connections between prenatal PFAS exposure and the placental structure and efficiency. Based on 712 maternal–fetal dyads in the Ma’anshan Birth Cohort, we analyzed associations between individual and mixed PFAS exposure and placental measures. We repeatedly measured 12 PFAS in the maternal serum during pregnancy. Placental weight, scaling exponent, chorionic disc area, and disc eccentricity were used as the outcome variables. Upon adjusting for confounders and implementing corrections for multiple comparisons, we identified positive associations between branched perfluorohexane sulfonate (br-PFHxS) and 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA) with placental weight. Additionally, a positive association was observed between br-PFHxS and the scaling exponent, where a higher scaling exponent signified reduced placental efficiency. Based on neonatal sex stratification, female infants were found to be more susceptible to the adverse effects of PFAS exposure. Mixed exposure modeling revealed that mixed PFAS exposure was positively associated with placental weight and scaling exponent, particularly during the second and third trimesters. Furthermore, br-PFHxS and 6:2 Cl-PFESA played major roles in the placental measures. This study provides the first epidemiological evidence of the relationship between prenatal PFAS exposure and placental measures.

孕妇产前接触全氟烷基和多氟烷基物质（PFASs）是不可避免的。然而，关于产前PFAS暴露与胎盘结构和效率之间联系的研究很少。基于马鞍山出生队列中的712例母胎二人组，我们分析了个体和混合PFAS暴露与胎盘测量之间的关联。在怀孕期间反复测量了母体血清中的12种PFAS。胎盘重量、缩放指数、绒毛膜椎间盘面积和椎间盘偏心率作为结局变量。在调整混杂因素并对多重比较进行校正后，发现支链全氟己烷磺酸盐（br-PFHxS）和 6：2 氯化多氟醚磺酸盐（6：2 Cl-PFESA）与胎盘重量呈正相关。此外，观察到 br-PFHxS 与缩放指数呈正相关，其中较高的缩放指数表示胎盘效率降低。根据新生儿性别分层，发现女婴更容易受到PFAS暴露的不利影响。混合暴露模型显示，混合PFAS暴露与胎盘重量和鳞屑指数呈正相关，特别是在妊娠中期和晚期。此外，br-PFHxS 和 6：2 Cl-PFESA 在胎盘测量中起主要作用。这项研究提供了产前PFAS暴露与胎盘测量之间关系的首个流行病学证据。