肠道微生物群对代谢性疾病的影响:基于微重力的新视角

 Infuence of gut microbiome on metabolic diseases: a new perspective based on microgravity

肠道微生物群对代谢性疾病的影响:基于微重力的新视角

Author：Wanxin Wu，Junjie Ren，Maozhen Han，Binbin Huang

Source：https://doi.org/10.1007/s40200-024-01394-7

Purpose：Microgravity, characterized by gravity levels of 10⁻³-10⁻⁶g, has been found to signifcantly impair various physiological systems in astronauts, including cardiovascular function, bone density, and metabolism. With the recent surge in human spacefight, understanding the impact of microgravity on biological health has become paramount.

Methods：A comprehensive literature search was performed using the PubMed database to identify relevant publications pertaining to the interplay between gut microbiome, microgravity, space environment, and metabolic diseases.

Results：This comprehensive review primarily focuses on the progress made in investigating the gut microbiome and its association with metabolic diseases under microgravity conditions. Microgravity induces notable alterations in the composition, diversity, and functionality of the gut microbiome. These changes hold direct implications for metabolic disorders such as cardiovascular disease (CVD), bone metabolism disorders, energy metabolism dysregulation, liver dysfunction, and complications during pregnancy.

Conclusion：This novel perspective is crucial for preparing for deep space exploration and interstellar migration, where understanding the complex interplay between the gut microbiome and metabolic health becomes indispensable.

目的：微重力环境下，重力水平为10^-3至10^-6g，已被发现会显著损害宇航员的多种生理系统，包括心血管功能、骨密度和代谢。随着近期人类太空探索的激增，了解微重力对生物健康的影响变得尤为重要。

方法：本研究通过PubMed数据库进行全面文献检索，以确定与肠道微生物组、微重力、太空环境和代谢性疾病之间相互作用相关的相关出版物。

结果：本综述主要关注在微重力条件下研究肠道微生物组及其与代谢性疾病的相关性方面所取得的进展。微重力会引起肠道微生物组的组成、多样性和功能发生显著变化。这些变化直接关联于代谢紊乱，如心血管疾病（CVD）、骨代谢紊乱、能量代谢失调、肝功能异常和妊娠并发症等。

结论：这种新的视角对于准备进行深空探测和星际迁徙至关重要，其中了解肠道微生物组与代谢健康之间的复杂相互作用变得至关重要。