青少年抑郁症与成人自杀行为关系的系统评价和荟萃分析

Association between adolescent depression and adult suicidal behavior: A systematic review and meta-analysis    

青少年抑郁症与成人自杀行为关系的系统评价和荟萃分析

Authors: Wang C, Tong Y, Tang T, Wang X, Fang L, Wen X, Su P, Wang J, Wang G.

Source：Asian J Psychiatr. 2024 Jul 29;100:104185. doi: 10.1016/j.ajp.2024.104185.

Abstract

This meta-analysis aims to estimate the association between adolescent depression and adult suicidal behavior, while systematically evaluating gender differences reported in literature. A random-effects model was used to determine the pooled association, reporting odds ratios (ORs) with corresponding 95 % confidence intervals (CIs). Nine articles comprising over 6084 adolescents together showed that people with a history of depression in adolescence are more likely to gain suicidal behaviors during adulthood (OR = 3.97, 95 % Cl: 2.79, 5.63). Sex-specific analysis indicated that males who experienced depression in adolescence developed a higher incidence of suicidal behavior in adulthood compared to females with a similar history (Males: OR = 3.61, 95 % Cl: 1.02, 12.78; Females: OR = 3.56, 95 % Cl: 1.71, 7.43). Furthermore, suicide attempts emerged as the predominant outcome among various suicidal behaviors (OR = 3.43, 95 % Cl: 1.75, 6.71). This meta-analysis provides robust evidence that depression in adolescence significantly increases the risk of suicidal behavior in adulthood.

Keywords: Adolescent; Adult; Depression; Suicidal behavior.

摘要

这项荟萃分析旨在估计青少年抑郁症与成人自杀行为之间的关联，同时系统地评估文献中报告的性别差异。使用随机效应模型确定合并相关性，报告比值比（OR）和相应的95%置信区间（CI）。9篇包含超过6084名青少年的文章显示，青少年期有抑郁史的人更容易在成年后获得自杀行为（OR = 3.97，95%CI：2.79，5.63）。性别特异性分析表明，与具有类似病史的女性相比，青春期经历抑郁的男性在成年后发生自杀行为的发生率更高（男性：OR = 3.61，95% CI：1.02，12.78;女性：OR = 3.56，95% CI：1.71，7.43）。此外，自杀未遂是各种自杀行为的主要结局（OR = 3.43，95%CI：1.75，6.71）.这项荟萃分析提供了强有力的证据，表明青春期抑郁症会显著增加成年后自杀行为的风险。

关键词：青少年;成人;抑郁;自杀行为。