探索评估邻苯二甲酸酯长期暴露的非侵入性矩阵：范围审查

Exploring noninvasive matrices for assessing long-term exposure to phthalates: a scoping review

探索评估邻苯二甲酸酯长期暴露的非侵入性矩阵：范围审查

Authors: Chen LW, Chen X, Mo HY, Shan CH, Zhu RP, Gao H, Tao FB.

Source：Front Public Health. 2024 Aug 2;12:1411588. doi: 10.3389/fpubh.2024.1411588.

Abstract

The phthalic acid esters (PAEs) are one class of the most abundant and frequently studied pseudo-persistent organic pollutants. Noninvasive urine is an effective substrate for evaluating PAE exposure, but repeated sampling is needed to overcome this bias. This adds much work to on-site collection and the cost of detection increases exponentially. Therefore, the aim of this study was to conduct a scope review to describe the detection methods and validity of the use of other noninvasive matrices, such as nails and hair, for assessing long-term exposure to PAEs. The PubMed, Web of Science and China National Knowledge Infrastructure (CNKI), electronic databases were searched from 1 January 2000 to 3 April 2024, and 12 studies were included. Nine and three studies used hair and nails, respectively, as noninvasive matrices for detecting PAE exposure. Five articles compared the results of nail or hair and urine tests for validity of the assessment of PAE exposure. The preprocessing and detection methods for these noninvasive samples are also described. The results of this review suggest that, compared with nails, hair may be more suitable as a noninvasive alternative matrix for assessing long-term exposure to PAEs. However, sample handling procedures such as the extraction and purification of compounds from hair are not uniform in various studies; therefore, further exploration and optimization of this process, and additional research evidence to evaluate its effectiveness, are needed to provide a scientific basis for the promotion and application of hair detection methods for assessing long-term PAE exposure levels.

Keywords: hair; long-term exposure; nail; noninvasive matrices; phthalate acid esters.

摘要

邻苯二甲酸酯（PAEs）是一类含量最丰富、研究最多的拟持久性有机污染物。非侵入性尿液是评估PAE暴露的有效底物，但需要重复采样以克服这种偏倚。这给现场收集工作增加了很多工作量，检测成本也呈指数级增长。因此，本研究的目的是进行范围审查，以描述使用其他非侵入性基质（例如指甲和头发）评估长期暴露于邻苯二甲酸酯的检测方法和有效性。检索PubMed、Web of Science和中国知网（CNKI）电子数据库，检索时间为2000年1月1日至2024年4月3日，共纳入12篇研究。9项和3项研究分别使用头发和指甲作为检测PAE暴露的非侵入性基质。5篇文章比较了指甲或毛发和尿液检测的结果，以评估PAE暴露的有效性。本文还介绍了这些非侵入性样品的预处理和检测方法。本综述的结果表明，与指甲相比，头发可能更适合作为评估长期暴露于PAEs的非侵入性替代基质。然而，各项研究中头发中化合物的提取和纯化等样品处理程序并不统一，因此需要进一步探索和优化该工艺，并提供额外的研究证据来评估其有效性，为头发检测方法的推广和应用提供科学依据，以评估长期邻苯二甲酸酯暴露水平。

关键词：头发;长期接触;指甲;非侵入性基质;邻苯二甲酸酯。