尿烷基间苯二酚代谢物，全麦小麦和黑麦摄入量的生物标志物，与肝脏脂肪和其他脂肪指标有益相关

Urinary alkylresorcinol metabolites, biomarkers of whole grain wheat and rye intake, are beneficially associated with liver fat and other fat measures

尿烷基间苯二酚代谢物，全麦小麦和黑麦摄入量的生物标志物，与肝脏脂肪和其他脂肪指标有益相关

Authors: Sun Z, Shao Y, Zhang X, Zhou Z, Ye S, Liu M, Lv Y, Xie S, Cao H, Zhang Z, Yang W.

Source：Food Funct. 2024 Aug 12;15(16):8488-8495. doi: 10.1039/d4fo01248h.

Abstract

Aims: Epidemiological studies that use dietary biomarkers to investigate the association between whole grain intake and the risk of obesity are sparse. We assessed the association between urinary alkylresorcinol metabolites including 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA) and 3,5-dihydroxybenzoic acid (DHBA), biomarkers of whole grain wheat and rye intake, and body fat measures. Methods: We measured urinary excretion of DHPPA and DHBA, body weight, height, and circumferences of the waist and hip at the baseline and again after 1-year in a representative sample of 306 community-dwelling adults in Huoshan, China. We also measured liver fat accumulation [indicated by the controlled attenuation parameter (CAP)] and other body composition after 1 year. Multivariate-adjusted linear models and linear mixed-effects models were used to analyze single measurement and repeated measurements, respectively. Results: Each 1 μg g^-1 creatinine increase in urinary DHPPA levels was associated with 0.21%, 0.23%, 3.64%, and 4.80% decrease in body weight, body mass index (BMI), body fat mass (BFM) and visceral fat level (VFL), respectively (all P < 0.05). Higher DHBA levels were inversely associated with CAP (percentage difference per 1 μg g^-1 creatinine increment: -1.98%, P < 0.05). Higher total urinary alkylresorcinol metabolite (DHPPA + DHBA) levels were associated with lower body weight, BMI, BFM, VFL, and CAP, with the percentage differences per 1 μg g^-1 creatinine increment of -0.27%, -0.27%, -3.79%, -5.12%, and -2.24%, respectively (all P < 0.05). Conclusions: Our findings suggest that the intake of whole grain wheat and rye, reflected by urinary DHPPA and DHBA, is favorably associated with liver fat and other fat measures.

摘要

目的：使用饮食生物标志物来研究全谷物摄入量与肥胖风险之间的关系的流行病学研究很少。我们评估了尿中烷基间苯二酚代谢物（包括3-（3，5-二羟基苯基）-1-丙酸（DHPPA）和3，5-二羟基苯甲酸（DHBA））、全麦和黑麦摄入量的生物标志物和体脂测量之间的相关性。方法：我们在霍山，中国的306个社区居住的成年人的代表性样本中，在基线和1年后再次测量了DHPPA和DHBA的尿排泄量、体重、身高和腰围和臀围。我们还测量了肝脏脂肪积累[由受控衰减参数（CAP）表示]和1年后的其他身体成分。分别采用多元校正线性模型和线性混合效应模型分析单次测量和重复测量。结果：尿DHPPA肌酐每增加1 μg g^-1，体重、体重指数（BMI）、体脂量（BFM）和内脏脂肪水平（VFL）分别下降0.2 1%、0.2 3%、3.6 4%和4.80%（P均0.0 5）。较高的DHBA水平与CAP呈负相关（每1 μg g^-1肌酐增量的百分比差异：-1.98%，P0.05）。较高的总尿烷基间苯二酚代谢物（DHPPA + DHBA）水平与较低的体重、BMI、BFM、VFL和CAP相关，每1 μg g^-1肌酐增量的百分比差异分别为-0.27%、-0.27%、-3.79%、-5.12%和-2.24%（所有P0.05）。结论：我们的研究结果表明，全麦小麦和黑麦的摄入量，反映了尿DHPPA和DHBA，是有利的肝脏脂肪和其他脂肪措施。