子痫前期与后代血压的关系:系统回顾和荟萃分析

Purpose of Review

Pregnancy-induced preeclampsia is a severe pregnancy complication and preeclampsia has been associated with an increased risk of chronic hypertension for offspring. However, the magnitude of the overall effect of exposure to preeclampsia in pregnancy on blood pressure (BP) in offspring is unknown. This systematic review and meta-analysis was sought to systematically assess the effects of preeclampsia on the BP of the offspring.

Recent Findings

Of 2550 publications identified, 23 studies were included. The meta-analysis indicated that preeclampsia increases the potential risk of hypertension in offspring. Systolic blood pressure (SBP) was 2.0 mm Hg (95% CI: 1.2, 2.8) and diastolic blood pressure (DBP) was 1.4 mm Hg (95% CI: 0.9, 1.9) higher in offspring exposed to pre-eclampsia in utero, compared to those born to normotensive mothers. The correlations were similar in stratified analyses of children and adolescents by sex, geographic area, ages, and gestational age.

Summary

During childhood and young adulthood, the offspring of pregnant women with preeclampsia are at an increased risk of high BP. It is crucial to monitor their BP.

摘要
目的
妊娠性子痫前期是一种严重的妊娠并发症，子痫前期与后代患慢性高血压的风险增加有关。然而，妊娠期暴露于先兆子痫对后代血压(BP)的总体影响程度尚不清楚。本系统综述和荟萃分析旨在系统地评估子痫前期对后代血压的影响。

结果
在确定的2550份出版物中，包括23项研究。荟萃分析表明，子痫前期增加了后代患高血压的潜在风险。与血压正常的母亲所生的后代相比，子宫内暴露于先兆子痫的后代收缩压(SBP)为2.0 mm Hg (95% CI: 1.2, 2.8)，舒张压(DBP)为1.4 mm Hg (95% CI: 0.9, 1.9)。在按性别、地理区域、年龄和胎龄对儿童和青少年进行分层分析时，相关性相似。

总结
在儿童期和青年期，子痫前期孕妇的后代患高血压的风险增加。监测他们的血压至关重要。