重性抑郁症患者辅助性T淋巴细胞改变的系统评价和荟萃分析：meta-analysis

Peripheral CD4⁺ T helper lymphocytes alterations in major depressive disorder: A systematic review and meta-analysis         

重性抑郁症患者辅助性T淋巴细胞改变的系统评价和荟萃分析：meta-analysis

Authors: Wang F, Zhu D, Cao L, Wang S, Tong Y, Xie F, Zhang X, Su P, Wang G.

Source：Neuroscience. 2024 Sep 13;555:145-155. doi: 10.1016/j.neuroscience.2024.07.027.

Abstract

Previous research has shown that patients with major depressive disorder (MDD) develop immune dysfunction. However, the exact alterations of cluster of differentiation (CD)4⁺ T helper (Th) lymphocytes in MDD remains unclear. This meta-analysis aimed to examine the specific changes in CD4⁺ Th cells. A comprehensive search of PubMed, EMBASE, Web of Science, and PsycINFO databases was conducted to identify studies investigating CD4⁺ Th, Th1, Th2, Th17, and T regulatory (Treg) cell counts in the peripheral blood of MDD patients and healthy controls (HCs), covering the period up to June 22, 2024. Our findings revealed that patients with MDD might exhibit higher CD4⁺ Th cells (SMD=0.26, 95 %CI, 0.02 to 0.50), CD4⁺/CD8⁺ cell ratios (SMD=0.51, 95 %CI, 0.14 to 0.89), Th1/Th2 cell ratios (SMD=0.15, 95 %CI, 0.01 to 0.30) and lower Th1 (SMD=-0.17, 95 %CI, -0.30 to -0.03), Th2 (SMD=-0.25, 95 %CI, -0.40 to -0.11), and Treg cells (SMD=-0.69, 95 %CI, -1.27 to -0.11). However, no significant difference was observed in terms of Th17 cells and Th17/Treg cell ratios between MDD patients and the HCs. Heterogeneity was large (I²:18.1-95.2 %), and possible sources of heterogeneity were explored (e.g., age, depression scale, country, and antidepressant use). Our findings indicate that peripheral CD4⁺ T cells in depressed patients exhibit features of adaptive immune dysfunction, as evidenced by increased CD4⁺ Th cells and CD4⁺/CD8⁺ and decreased Treg cells. These findings offer insights into the underlying mechanism of MDD.

Keywords: CD4(+) T helper cells; Major depressive disorder; T regulatory; Th1; Th17; Th2.

摘要

先前的研究表明，重度抑郁症（MDD）患者会出现免疫功能障碍。然而，MDD患者CD 4⁺ Th淋巴细胞的确切变化尚不清楚。本荟萃分析旨在研究CD 4⁺ Th细胞的特异性变化。对PubMed、EMBASE、Web of Science和PsycINFO数据库进行了全面检索，以识别研究MDD患者和健康对照（HC）外周血中CD 4⁺Th、Th 1、Th 2、Th 17和调节性T（Treg）细胞计数的研究，涵盖时间截至2024年6月22日。结果表明，MDD患者的CD 4 ⁺ Th细胞（SMD=0.26，95%CI，0.02 ~ 0.50）、CD 4 + /CD 8+细胞比值（SMD=0.26，95%CI，0.02 ~ 0.50（SMD=0.51，95% CI，0.14 - 0.89），Th 1/Th 2细胞比率（SMD=0.15，95% CI，0.01 - 0.30）和Th 1较低在一些实施方案中，所述细胞是T细胞（SMD=-0.17，95%CI，-0.30至-0.03）、Th 2（SMD=-0.25，95%CI，-0.40至-0.11）和Treg细胞（SMD=-0.69，95%CI，-1.27至-0.11）。然而，MDD患者和HC之间的Th 17细胞和Th 17/Treg细胞比率没有观察到显著差异。异质性很大（^I2：18.1- 95.2%），并探索了异质性的可能来源（例如，年龄、抑郁量表、国家和抗抑郁药使用）。我们的研究结果表明，抑郁症患者的外周血CD 4⁺ T细胞表现出适应性免疫功能障碍的特征，表现为CD 4⁺ Th细胞和CD 4⁺/CD 8^+增加和Treg细胞减少。这些发现提供了深入了解MDD的潜在机制。

关键词：CD 4（+）T辅助细胞;重性抑郁症; T调节; Th 1; Th 17; Th 2。