孕前接触邻苯二甲酸酯对健康的危害：流行病学研究的范围审查

Health hazards of preconception phthalate exposure: A scoping review of epidemiology studies          

孕前接触邻苯二甲酸酯对健康的危害：流行病学研究的范围审查

Authors: Chen LW, Mo HY, Shan CH, Chen X, Han C, Tao FB, Gao H.

Source：Ecotoxicol Environ Saf. 2024 Sep 1;282:116763. doi: 10.1016/j.ecoenv.2024.116763.

Abstract

There is a close relationship between preconception health and maternal and child health outcomes, and the consequences may be passed down from generation to generation. In 2018, Lancet published three consecutive articles emphasizing the importance of the preconception period. Phthalic acid ester (PAE) exposure during this period may affect gametogenesis and epigenetic information in gametophytes, thereby affecting embryonic development and offspring health. Therefore, this article reviews the effects of parental preconception PAE exposure on reproductive/birth outcomes and offspring health, to provide new evidence on this topic. We searched Web of Science, MEDLINE (through PubMed), the China National Knowledge Infrastructure (CNKI), ScienceDirect, and the VIP Journal Library from the date of database establishment to July 3, 2024. Finally, 12 articles were included. Three studies investigated the health hazards (effects on birth weight, abortion, etc.) of women's preconception PAE exposure. Nine studies involved both parents. Nine studies considered the impacts of PAE preconception exposure on reproductive/birth outcomes, focusing on birth weight, pregnancy loss, preterm birth, embryo quality, and placental weight. Three studies considered the impacts of preconception PAE exposure on offspring behavior. The results of this review suggested that parental preconception PAE exposure may have an impact on reproductive/birth outcomes and offspring behavior, including birth weight, child behavior, and dietary behavior. However, studies on the health hazards of preconception PAE exposure are relatively scarce, and the outcomes of current studies are varied. It is necessary to use systematic reviews to verify an accurate research question to provide recommendations for public health policy making.

Keywords: Birth outcomes; Child behavior; Eating behavior; Phthalate; Preconception.

摘要

孕前健康与母婴健康结果之间存在密切关系，其后果可能代代相传。2018年，《柳叶刀》连续发表了三篇文章，强调了孕前期的重要性。在此期间暴露于邻苯二甲酸酯（PAE）可能会影响配子体的配子发生和表观遗传信息，从而影响胚胎发育和后代健康。本文综述了父母孕前PAE暴露对生殖/出生结局和后代健康的影响，以期为这一课题提供新的证据。我们检索了Web of Science、MEDLINE（通过PubMed）、中国知网（CNKI）、ScienceDirect和VIP期刊库，数据库建立日期至2024年7月3日。最终纳入12篇文章。三项研究调查了健康危害（对出生体重、堕胎等的影响）。女性怀孕前的PAE暴露。九项研究涉及父母双方。9项研究考虑了PAE孕前暴露对生殖/出生结局的影响，重点关注出生体重、妊娠丢失、早产、胚胎质量和胎盘重量。三项研究考虑了孕前PAE暴露对后代行为的影响。本综述的结果表明，父母孕前PAE暴露可能对生殖/出生结局和后代行为产生影响，包括出生体重、儿童行为和饮食行为。然而，关于孕前PAE暴露对健康危害的研究相对较少，目前的研究结果各不相同。有必要使用系统评价来验证一个准确的研究问题，为公共卫生政策制定提供建议。

关键词：出生结果;儿童行为;饮食行为;邻苯二甲酸酯;孕前。